Systematic Searching Support at Hardin Library
What is a Systematic Review?
Aim: To collect, appraise, and synthesize all empirical evidence related to a specific question, following specific criteria to ensure comprehensiveness and to minimize bias.
Synonyms: Cochrane Review (a systematic review completed by a Cochrane review group)
Notes about Methodology
- Clearly stated set of objectives with pre-defined inclusion criteria with an explicit, reproducible methodology
- Systematic search that attempts to identify all potential studies
- Independent reviewers
- Quality assessment/risk of bias determination
- Narrative synthesis of findings of the included studies
- Analysis generally includes clinical implications
- Grey literature should be considered to reduce bias
Methodology Guidance
- Cochrane Handbook for Systematic Reviews of InterventionsFree resource updated in 2021 that provides conduct of Cochrane intervention reviews
- Cochrane Handbook for Systematic Reviews of Diagnostic Test AccuracyFree resource for Cochrane reviews about diagnosis
- Systematic Reviews from Centre for Reviews and DisseminationFree resource providing guidance of conduct of systematic reviews
- AMSTAR: A MeaSurement Tool to Assess systematic ReviewsFree resource that can be used for conduct guidance or to critically appraise systematic reviews
Reporting Standards
PRISMA is an international group of methodology experts dedicated to improving reporting quality of reviews. Most journals that accept systematic reviews will adhere to the PRISMA standards and will require a PRISMA flow diagram.
Exemplars
This reference may serve as an example of a quality project:
McDanel, J., Schweizer, M., Crabb, V., Nelson, R., Samore, M., Khader, K., Blevins, A. E., Diekema, D., Chiang, H. Y., Nair, R., & Perencevich, E. (2017). Incidence of Extended-Spectrum beta-Lactamase (ESBL)-Producing Escherichia coli and Klebsiella Infections in the United States: A Systematic Literature Review. Infect Control Hosp Epidemiol, 38(10), 1209-1215. https://doi.org/10.1017/ice.2017.156 View full text
- Last Updated: May 23, 2025 12:07 PM
- URL: https://guides.lib.uiowa.edu/reviewshealthsciences
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